Cold hands cold heart skin#
skin and core) into neural inputs allows the central nervous system to produce thermal sensations (Darian-Smith, 1984). 2014).īeside its role in autonomic body temperature regulation (Cotter & Taylor, 2005), the transduction of the temperature of tissues (e.g. Indeed, in neurological diseases such as multiple sclerosis, impairments in thermosensory integration contribute to autonomic dysfunction (Davis et al. The physiological importance of thermoreception is particularly evident in the context of pathological conditions associated with thermosensory deficit. thermoreception, represents an important sensory feature that allows humans to regulate effectively the autonomic and behavioural thermoregulatory responses required to maintain thermal homeostasis and ensure survival (Hensel, 1973 Cabanac, 2010 Filingeri, 2016). Sensing temperature changes in the external and internal environment, i.e. In highlighting a novel feature of human temperature integration, these findings point to the existence of an endogenous thermosensory system that could modulate local skin thermal sensitivity in relationship to whole-body thermal states. Overall, large decreases in T sk significantly facilitated warm but not cold sensory processing of local thermal stimuli, in a dose-dependent fashion. Linear regression indicated a 1.2% ☌ −1 increase in warm thermosensitivity with whole-body skin cooling. While thermosensitivity to local skin cooling remained unchanged ( P = 0.831), sensitivity to skin warming increased significantly at each level of T sk for all skin regions. The cooling protocol resulted in large progressive reductions in T sk, with minimal changes (∼0.08☌) in rectal temperature. On four separate occasions, eight men (27 ± 5 years old) underwent a 30 min whole-body cooling protocol (water-perfused suit temperature, 5☌), during which a quantitative thermosensory test, consisting of reporting the perceived magnitude of warming and cooling stimuli (☘☌ from 30☌ baseline) applied to the hand (palm/dorsum) and foot (sole/dorsum), was performed before cooling and every 10 min thereafter. Hence, we tested whether progressive decreases in whole-body mean skin temperature ( T sk a large conditioning stimulus) alter the magnitude estimation of local warming and cooling stimuli applied to hairy and glabrous skin. In resembling the central mechanisms underlying endogenous analgesia, our findings point to the existence of an endogenous thermosensory system in humans that could modulate local skin thermal sensitivity to facilitate thermal behaviour.Īlthough inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has not been explored. Progressive decreases in whole-body mean skin temperature (the conditioning stimulus) significantly increased local thermosensitivity to skin warming but not cooling (the testing stimuli) in a dose-dependent fashion. What is the main finding and its importance? We asked whether contextual modulation also exists in human temperature integration. Investigations on inhibitory/facilitatory modulation of vision, touch and pain show that conditioning stimuli outside the receptive field of testing stimuli modulate the central processing of visual, touch and painful stimuli. With Amanda's death, Dani, in desperate need of a heart transplant, gets a second chance.What is the central question of this study?
During a brilliant gymnastic routine, Amanda slips and a young life with so much potential comes to an end. One girl lives a life of x-rays, tests, and endless hospital visits while the other is on the fast-track to the national championship. Fourteen-year-old Amanda puts her heart and soul into competitive gymnastics. This is Jill Wolfson's latest novel and it addresses subjects like life-threatening illness, loss, and the gift of life through organ donation.įifteen-year-old Dani was born with her heart on the wrong side of her body, a condition called dextrocardia. It was first published in 2009 by Henry Holt and Company. JSTOR ( November 2012) ( Learn how and when to remove this template message)Ĭold Hands, Warm Heart is a young adult novel by Jill Wolfson.Please improve this by adding secondary or tertiary sources.įind sources: "Cold Hands, Warm Heart" novel – news This article relies too much on references to primary sources.